Three scientists from the United States and Denmark were jointly awarded this year’s Nobel Prize in chemistry for developing a way of “snapping molecules together” that can be used to design better medicines.
Carolyn R Bertozzi, Morten Meldal and K. Barry Sharpless were cited for their work on click chemistry and bioorthogonal reactions, which are used to make cancer drugs, map DNA and create materials that are tailored to a specific purpose.
“It’s all about snapping molecules together,” said Johan Aqvist, a member of the Royal Swedish Academy of Sciences that announced the winners Wednesday at the Karolinska Institute in Stockholm, Sweden.
Sharpless, who previously won a Nobel Prize in 2001 and is now the fifth person to receive the award twice, first proposed the idea for connecting molecules using chemical “buckles” around the turn of the millennium, said Aqvist.
Meldal, based at the University of Copenhagen, Denmark, and Sharpless, who is affiliated with Scripps Research, California, independently found the first such candidates that would easily snap together with each other but not with other molecules, leading to applications in the manufacture of medicines and polymers.